Motor Effects of 1 , 3-Disubstituted 8-Styrylxanthines as A 1 and A 2 Adenosine-Receptor Antagonists in Rats

@inproceedings{Len2013MotorEO,
  title={Motor Effects of 1 , 3-Disubstituted 8-Styrylxanthines as A 1 and A 2 Adenosine-Receptor Antagonists in Rats},
  author={Ilhuicamina Daniel Lim{\'o}n-P{\'e}rez de Le{\'o}n and Mar{\'i}a del Carmen Parra-Cid and Alejandro Mu{\~n}oz-Zurita and Sa{\'u}l Alejandro Merino-Contreras and Sara Montiel-Smith and Socorro Meza-Reyes and Gerardo Ram{\'i}rez-Mej{\'i}a and Jes{\'u}s Sandoval-Ram{\'i}rez},
  year={2013}
}
A series of 1,3-substituted 8-styrylxanthines (11a-d) was synthesized, under chemoand regioselective conditions, in a good overall yield. The compounds showed affinity towards both A1 and A2A-adenosine receptors by radioligand binding by means of in vitro assays. The (E)-3-ethyl-1-propyl-8-styrylxanthine (11a) showed the greatest affinity towards the A2A… CONTINUE READING