Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review

@inproceedings{AlvesCruzeiro2016MotorDA,
  title={Motor Dysfunctions and Neuropathology in Mouse Models of Spinocerebellar Ataxia Type 2: A Comprehensive Review},
  author={Joao Miguel da Conceiçao Alves-Cruzeiro and Liliana Mendonça and Lu{\'i}s Pereira de Almeida and Cl{\'e}vio N{\'o}brega},
  booktitle={Front. Neurosci.},
  year={2016}
}
Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant ataxia caused by an expansion of CAG repeats in the exon 1 of the gene ATXN2, conferring a gain of toxic function that triggers the appearance of the disease phenotype. SCA2 is characterized by several symptoms including progressive gait ataxia and dysarthria, slow saccadic eye movements, sleep disturbances, cognitive impairments, and psychological dysfunctions such as insomnia and depression, among others. The available treatments… CONTINUE READING
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