Motor-Circuit Communication Matrix from Spinal Cord to Brainstem Neurons Revealed by Developmental Origin

@article{Pivetta2014MotorCircuitCM,
  title={Motor-Circuit Communication Matrix from Spinal Cord to Brainstem Neurons Revealed by Developmental Origin},
  author={Chiara Pivetta and Maria Soledad Esposito and Markus Sigrist and Silvia Arber},
  journal={Cell},
  year={2014},
  volume={156},
  pages={537-548}
}
Accurate motor-task execution relies on continuous comparison of planned and performed actions. Motor-output pathways establish internal circuit collaterals for this purpose. Here we focus on motor collateral organization between spinal cord and upstream neurons in the brainstem. We used a newly developed mouse genetic tool intersectionally with viruses to uncover the connectivity rules of these ascending pathways by capturing the transient expression of neuronal subpopulation determinants. We… CONTINUE READING
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