Motor Axon Subpopulations Respond Differentially to the Chemorepellents Netrin-1 and Semaphorin D

@article{VarelaEchavarra1997MotorAS,
  title={Motor Axon Subpopulations Respond Differentially to the Chemorepellents Netrin-1 and Semaphorin D},
  author={Alfredo Varela-Echavarr{\'i}a and A. K. Tucker and Andreas W P{\"u}schel and Sarah Guthrie},
  journal={Neuron},
  year={1997},
  volume={18},
  pages={193-207}
}
During development, growing motor axons are excluded from the ventral midline of the neural tube by diffusible chemorepellents emanating from this region. Molecular candidates for this chemorepellent activity include semaphorin D and netrin-1; the latter is known to repel trochlear motor axons. Qualitatively or quantitatively different responses to these molecules might underlie the initial deflection from the midline and subsequent segregation of motor axon trajectories. To test this idea, we… CONTINUE READING
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