Motor Axon Subpopulations Respond Differentially to the Chemorepellents Netrin-1 and Semaphorin D

  title={Motor Axon Subpopulations Respond Differentially to the Chemorepellents Netrin-1 and Semaphorin D},
  author={Alfredo Varela-Echavarr{\'i}a and A. K. Tucker and Andreas W P{\"u}schel and Sarah Guthrie},
During development, growing motor axons are excluded from the ventral midline of the neural tube by diffusible chemorepellents emanating from this region. Molecular candidates for this chemorepellent activity include semaphorin D and netrin-1; the latter is known to repel trochlear motor axons. Qualitatively or quantitatively different responses to these molecules might underlie the initial deflection from the midline and subsequent segregation of motor axon trajectories. To test this idea, we… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 102 extracted citations

Analysis of a Zebrafish semaphorin reveals potential functions in vivo.

Developmental dynamics : an official publication of the American Association of Anatomists • 1999
View 4 Excerpts
Highly Influenced

Axon pathfinding for locomotion.

Seminars in cell & developmental biology • 2017


Publications referenced by this paper.
Showing 1-10 of 39 references

Differential expression of LIM homeobox genes among motor neuron subpopulations in the developing chick brainstem

A. Varela-Echavarrı́a, S. Guthrie
Mol . Cell Neurosci • 1996
View 4 Excerpts
Highly Influenced

4 , 116 – 120 . molecules ?

S. Guthrie, A. Pini
Eur . J . Neurosci . • 1995
View 6 Excerpts
Highly Influenced

Netrins arediffusible chemotropic factors for commissural

T. E. Kennedy, T. Serafini, J. R. de la Torre
Dev . Biol . • 1994
View 3 Excerpts
Highly Influenced

Collagen gel coculture of neural

A. W. Püschel
View 1 Excerpt

Decorin in the developing mouse moattracts crossed axons and chemorepels uncrossed axons in thenervous system : expression in the floor plate and binding to netrin - 1 . vertebrate brain

A. D. Lander
Neuron Soc . Neurosci . • 1996

Similar Papers

Loading similar papers…