Motoo Kimura. 13 November 1924—13 November 1994

@article{Crow1997MotooK1,
  title={Motoo Kimura. 13 November 1924—13 November 1994},
  author={James F. Crow},
  journal={Biographical Memoirs of Fellows of the Royal Society},
  year={1997},
  pages={255 - 265}
}
  • J. Crow
  • Published 1 November 1997
  • Biology, Medicine
  • Biographical Memoirs of Fellows of the Royal Society
Motoo Kimura's research contributions can be divided into two parts. The first is a series of papers on theoretical population genetics, the quality and quantity of which place him as the successor to the great trinity, R.A. Fisher, J.B.S. Haldane and Sewall Wright. The second is his neutral theory, the idea that the bulk of molecular evolutionary changes are driven by mutation and random chance, rather than by natural selection. The neutral theory brought him fame far beyond the confines of… 
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Motoo Kimura (1924–1994)

References

SHOWING 1-10 OF 25 REFERENCES
A MODEL OF A GENETIC SYSTEM WHICH LEADS TO CLOSER LINKAGE BY NATURAL SELECTION
TLDR
A specific model in which selection leads to closer linkage will be examined, and the reversal of selective value of alleles at one locus according to which allele is present at another is not sufficient to maintain a stable polymorphism.
On the change of population fitness by natural selection2 3
TLDR
A general equation for the role of additive, dominance, and epistatic components of fitness in determining the rate of change in population fitness is given and claims that this law should hold the same position among the biological sciences as the second law of thermodynamics in physical sciences.
The neutral theory of molecular evolution and the world view of the neutralists.
TLDR
The present status of the neutral theory is reviewed, including discussions of such topics as "molecular evolutionary clock," very high evolutionary rates observed in RNA viruses, a deviant coding system found in Mycoplasm together with the concept of mutation-driven neutral evolution, and the origin of life.
DNA and the neutral theory.
  • M. Kimura
  • Biology, Medicine
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1986
TLDR
The recent outburst of DNA sequence data lends strong support to the neutral theory both with respect to evolutionary base substitutions and DNA polymorphism, including rapid evolutionarybase substitutions in pseudogenes.
THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION.
TLDR
This article proposes to examine some of the population consequences of a system of different isoalleles whose frequency in the population is determined by the mutation rate and by random drift, and considers three possibilities: A system of selectively neutral isoallels, a systemof mutually heterotic alleles, and a mixture of heterotic and harmful mutants.
SOME METHODS FOR TREATING CONTINUOUS STOCHASTIC PROCESSES IN POPULATION GENETICS
TLDR
A single locus with a pair of alleles A and A' segregating in a finite Mendelian population is considered and the stochastic process in the change of gene frequency is regarded as a collection of sample paths.
The number of heterozygous nucleotide sites maintained in a finite population due to steady flux of mutations.
TLDR
The number of heterozygous sites per individual and some related quantities that represent the statistical properties of the mutant frequency distribution are investigated, assuming that a very large number of independent sites are available for mutation.
Preponderance of synonymous changes as evidence for the neutral theory of molecular evolution
TLDR
By comparative studies of messenger RNA (mRNA) sequences reliable estimates can be obtained of the evolutionary rates (in terms of mutant substitutions) at the third positions of the codon, and that the estimates conform remarkably well with the framework of the neutral theory.
The rate of molecular evolution considered from the standpoint of population genetics.
  • M. Kimura
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1969
TLDR
Random gene frequency drift is playing an important role in determining the genetic structure of biological populations and genes in "living fossils" may be expected to have undergone as many DNA base substitutions as corresponding genes (proteins) in more rapidly evolving species.
The length of time required for a selectively neutral mutant to reach fixation through random frequency drift in a finite population.
  • M. Kimura
  • Medicine, Biology
    Genetical research
  • 1970
TLDR
The purpose of this note is to show that, for a neutral mutant, the entire probability distribution of the length of time until fixation can readily be derived from my previous results on the process of random genetic drift.
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