Motoneuron degeneration after facial nerve avulsion is exacerbated in presymptomatic transgenic rats expressing human mutant Cu/Zn superoxide dismutase.

@article{Ikeda2005MotoneuronDA,
  title={Motoneuron degeneration after facial nerve avulsion is exacerbated in presymptomatic transgenic rats expressing human mutant Cu/Zn superoxide dismutase.},
  author={Ken Ikeda and Masashi Aoki and Y. Kawazoe and Tsuyoshi Sakamoto and Yuichi Hayashi and Aya Ishigaki and Makiko Nagai and Rieko Kamii and Shinsuke Kato and Y. Itoyama and Kazuhiko Watabe},
  journal={Journal of neuroscience research},
  year={2005},
  volume={82 1},
  pages={63-70}
}
We investigated motoneuron degeneration after proximal nerve injury in presymptomatic transgenic (tg) rats expressing human mutant Cu/Zn superoxide dismutase (SOD1). The right facial nerves of presymptomatic tg rats expressing human H46R or G93A SOD1 and their non-tg littermates were avulsed, and facial nuclei were examined at 2 weeks postoperation. Nissl-stained cell counts revealed that facial motoneuron loss after avulsion was exacerbated in H46R- and G93A-tg rats compared with their non-tg… CONTINUE READING