Motoneuron BDNF/TrkB signaling enhances functional recovery after cervical spinal cord injury.

@article{Mantilla2013MotoneuronBS,
  title={Motoneuron BDNF/TrkB signaling enhances functional recovery after cervical spinal cord injury.},
  author={Carlos B. Mantilla and Heather M. Gransee and Wen-Zhi Zhan and Gary C. Sieck},
  journal={Experimental neurology},
  year={2013},
  volume={247},
  pages={101-9}
}
A C2 cervical spinal cord hemisection (SH) interrupts descending inspiratory-related drive to phrenic motoneurons located between C3 and C5 in rats, paralyzing the ipsilateral hemidiaphragm muscle. There is gradual recovery of rhythmic diaphragm muscle activity ipsilateral to cervical spinal cord injury over time, consistent with neuroplasticity and strengthening of spared, contralateral descending premotor input to phrenic motoneurons. Brain-derived neurotrophic factor (BDNF) signaling through… CONTINUE READING

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