Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes.

@article{Laviolette2002MotivationalSD,
  title={Motivational state determines the functional role of the mesolimbic dopamine system in the mediation of opiate reward processes.},
  author={Steven R Laviolette and Karim Nader and Derek van der Kooy},
  journal={Behavioural brain research},
  year={2002},
  volume={129 1-2},
  pages={17-29}
}
We have previously reported that mesolimbic dopamine (DA) substrates are critically involved in the rewarding effects of opiates only during states of opiate-dependence and withdrawal. However, in previously drug-naive animals, opiate reward is mediated through a DA-independent neural system. In the present study, we report that bilateral microinjections of a DA receptor antagonist, alpha-flupenthixol (0.3-3 microg/0.5 microl) into the nucleus accumbens (NAc), blocks morphine reward (10 mg/kg… CONTINUE READING

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