Motivational Disturbances and Effects of L-dopa Administration in Neurofibromatosis-1 Model Mice

@inproceedings{Wozniak2013MotivationalDA,
  title={Motivational Disturbances and Effects of L-dopa Administration in Neurofibromatosis-1 Model Mice},
  author={David F. Wozniak and Kelly A. Diggs-Andrews and Sara B Conyers and Carla M. Yuede and Joshua T. Dearborn and Jacquelyn A. Brown and Kazuhiro Tokuda and Yukitoshi Izumi and Charles F Zorumski and David H Gutmann},
  booktitle={PloS one},
  year={2013}
}
Children with neurofibromatosis type 1 (NF1) frequently have cognitive and behavioral deficits. Some of these deficits have been successfully modeled in Nf1 genetically-engineered mice that develop optic gliomas (Nf1 OPG mice). In the current study, we show that abnormal motivational influences affect the behavior of Nf1 OPG mice, particularly with regard to their response to novel environmental stimuli. For example, Nf1 OPG mice made fewer spontaneous alternations in a Y-maze and fewer arm… CONTINUE READING
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