Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats.

@article{Frye2013MotivatedBA,
  title={Motivated behaviors and levels of 3α,5α-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats.},
  author={Cheryl Anne Frye and Carolyn J. Koonce and Alicia A. Walf and Jamie C. Rusconi},
  journal={The journal of sexual medicine},
  year={2013},
  volume={10 7},
  pages={
          1692-706
        }
}
INTRODUCTION Progesterone (P4 ) and its product, 5α-pregnan-3α-ol-20-one (3α,5α-THP), act in the midbrain ventral tegmental area (VTA) to alter motivated behaviors, such as mating, and motor and anxiety behavior. Of interest is whether 3α,5α-THP formation requires the pregnane xenobiotic receptor (PXR), which is expressed in the midbrain of rats. AIM The role of PXR in the midbrain for 3α,5α-THP formation, which precedes modulation of motivated behaviors, was investigated. METHODS Rats had… CONTINUE READING

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