Motions of the substrate recognition duplex in a group I intron assessed by site-directed spin labeling.

@article{Grant2009MotionsOT,
  title={Motions of the substrate recognition duplex in a group I intron assessed by site-directed spin labeling.},
  author={Gian Paola G. Grant and Nathan Boyd and Daniel Herschlag and Peter Z Qin},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 9},
  pages={3136-7}
}
The Tetrahymena group I intron recognizes its oligonucleotide substrate in a two-step process. First, a substrate recognition duplex, called the P1 duplex, is formed. The P1 duplex then docks into the prefolded ribozyme core by forming tertiary contacts. P1 docking controls both the rate and the fidelity of substrate cleavage and has been extensively studied as a model for the formation of RNA tertiary structure. However, previous work has been limited to studying millisecond or slower motions… CONTINUE READING

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Advanced ESR Methods in Polymer Reaserch

K. A. Earle, D. Budil
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