Motion as a phenotype: the use of live-cell imaging and machine visual screening to characterize transcription-dependent chromosome dynamics

@article{Drubin2005MotionAA,
  title={Motion as a phenotype: the use of live-cell imaging and machine visual screening to characterize transcription-dependent chromosome dynamics},
  author={David A. Drubin and Arman M. Garakani and Pamela A. Silver},
  journal={BMC Cell Biology},
  year={2005},
  volume={7},
  pages={19 - 19}
}
BackgroundGene transcriptional activity is well correlated with intra-nuclear position, especially relative to the nuclear periphery, which is a region classically associated with gene silencing. Recently however, actively transcribed genes have also been found localized to the nuclear periphery in the yeast Saccharomyces cerevisiae. When genes are activated, they become associated with the nuclear pore complex (NPC) at the nuclear envelope. Furthermore, chromosomes are not static structures… CONTINUE READING

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CITES RESULTS, METHODS & BACKGROUND
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  • 2014
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 48 REFERENCES

New methods for automated phenotyping of complex cellular behaviors

  • The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • 2004
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Automatic tracking of particles in dynamic fluorescence microscopy

  • 3rd International Symposium on Image and Signal Processing and Analysis, 2003. ISPA 2003. Proceedings of the
  • 2003
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Reverse recruitment: the Nup84 nuclear pore subcomplex mediates Rap1/Gcr1/Gcr2 transcriptional activation.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL