Motile responses in outer hair cells

@article{Zenner1986MotileRI,
  title={Motile responses in outer hair cells},
  author={H. Zenner},
  journal={Hearing Research},
  year={1986},
  volume={22},
  pages={83-90}
}
  • H. Zenner
  • Published 1986
  • Medicine, Biology
  • Hearing Research
Motile responses of cochlear hair cells open new perspectives for the understanding of cochlear hearing mechanisms and hearing disorders located in hair cells. Direct visualization of hair cell motility was achieved by a method for the study of living isolated mammalian outer hair cells (OHCs) which has overcome some of the complexities in dealing with the heterogeneous organ of Corti. Electrophysiological giga-seal whole-cell recordings of single OHC prepared by this approach had revealed… Expand
Active radial and transverse motile responses of outer hair cells in the organ of corti
TLDR
The present report shows active transverse and radial motile responses of OHCs in the OC, which are electro-mechanical in situ processes and indicates how outer hair cell electromotility may influence hearing when it occurs within the mechanical framework of the OC. Expand
Osmoreceptors in Cochlear Outer Hair Cells
TLDR
The mammalian outer hair cells (OHCs) are mechanical effectors of the cochlea and any disturbance in the homeostasis of inner ear fluids may affect the functional properties of OHCs by NO via the activation of TRPV4, thereby influencing the delivery of auditory information. Expand
Outer hair cells as fast and slow cochlear amplifiers with a bidirectional transduction cycle.
TLDR
Steps of the sensory transduction in living mammalian hair cells are presented and it is revealed that in these cells, electro-mechanical mechanisms can induce fast and slow motile events. Expand
Mechanically induced length changes of isolated outer hair cells are metabolically dependent
TLDR
The finding that the bidirectional motile response of isolated outer hair cells induced by mechanical stimulation is dependent on the metabolic state of the cell distinguishes this type of motility from the electrically induced outer hair cell shape changes. Expand
Cochlear Receptor Potentials
Sensory processing in the cochlea is initiated when the hair cells respond to excitation by generating receptor potentials. Sensory transduction takes place in the organ of Corti, a strip of sensoryExpand
Motile responses of isolated guinea pig vestibular hair cells
TLDR
The possibility that fast tilting of the cuticular plate is a physiological movement involving the hair cells at the periphery of the vestibular receptors is discussed and the regulation of the Vestibular message at the apex of type I hair cells is also considered. Expand
Dissociation between the calcium-induced and voltage-driven motility in cochlear outer hair cells from the waltzing guinea pig.
TLDR
When intracellular calcium was increased with either the calcium ionophore, ionomycin or Ca2+/ATP (under permeabilized conditions with DMSO), length changes were significantly reduced for the outer hair cells from waltzing guinea pigs compared to the controls. Expand
The membrane-based mechanism of cell motility in cochlear outer hair cells.
TLDR
Direct support to the feedback hypothesis comes from the fact that OHCs posses a unique ability to change significantly their shape in response to electrical stimulation, a phenomenon called electromotility. Expand
Cochlear Mechanisms: Structure, Function, and Models
1. Hair Cell Ultrastructure.- Structural organization of the mammalian auditory hair cells in relation to micromechanics.- Observations on the cytoskeleton and related structures of mammalianExpand
Outer Hair Cells Possess Acetylcholine Receptors and Produce Motile Responses in the Organ of Corti
Active mechanical processes in the mammalian cochlea are considered to be new general mechanisms in hearing that differ from the classical description of the passive travelling wave of the basilarExpand
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References

SHOWING 1-10 OF 20 REFERENCES
Evoked mechanical responses of isolated cochlear outer hair cells.
TLDR
The microarchitecture of the organ of Corti permits length changes of outer hair cells in a manner that could significantly influence the mechanics of the cochlear partition and thereby contribute to the exquisite sensitivity of mammalian hearing. Expand
Reversible contraction of isolated mammalian cochlear hair cells
TLDR
Outer hair cells were isolated from the guinea pig cochlea using a micromechanical non-enzymatic procedure and the contractile event led to the production of a visible cytoplasmic network between the supranuclear area and the cuticular plate. Expand
Absence of myosin-like immunoreactivity in stereocilia of cochlear hair cells
TLDR
In semi-thin, transverse sections of quick-frozen, freeze-dried and plastic-embedded guinea pig organ of Corti, myosin-like immunostaining was restricted to the apical cytoplasm of hair cells and was not detected along the stereocilia. Expand
Graded and nonlinear mechanical properties of sensory hairs in the mammalian hearing organ
TLDR
Investigation of the mechanical properties of sensory hair bundles in the guinea pig organ of Corti reports that hair-bundle stiffness increases longitudinally towards the high-frequency end of the cochlea, decreases radially towards the outer rows of cells, and is greater for excitatory than for inhibitory deflection. Expand
Active control of sensory hair mechanics implied by susceptibility to media that induce contraction in muscle
TLDR
Results indicate that the sensory cells in the ear may possess a contractile machinery situated at the input end of the cell in the region of the sensory hairs and cuticular plate, and implies that hair cells can produce a mechanical output in response to sensory or synaptic stimuli. Expand
Actin filaments in sensory hairs of inner ear receptor cells
TLDR
The identity of the filaments of stereocilia in the crista ampullaris of the frog and guinea pig are concluded that they are composed of actin. Expand
Mechanoelectrical transduction by hair cells in the acousticolateralis sensory system.
  • A. Hudspeth
  • Biology, Medicine
  • Annual review of neuroscience
  • 1983
TLDR
The present review focuses on transduction in its more restricted, cellular sense, as the transfor­ mation of a mechanical stimulus into a conductance change and an elec­ trical response of the hair cell's membrane. Expand
An active process in cochlear mechanics
  • H. Davis
  • Medicine, Physics
  • Hearing Research
  • 1983
TLDR
Both the classical high-intensity system and the active low-level CA system are highly nonlinear and they combine to compress the great dynamic range of hearing into a much narrower range of mechanical movement of the cilia of the inner hair cells. Expand
Interactions between actin filaments and between actin filaments and membranes in quick-frozen and deeply etched hair cells of the chick ear
Replicas of the apical surface of hair cells of the inner ear (vestibular organ) were examined after quick freezing and rotary shadowing. With this technique we illustrate two previously undescribedExpand
Three sets of actin filaments in sensory cells of the inner ear. Identification and functional orientation determined by gel electrophoresis, immunofluorescence and electron microscopy
TLDR
The presence of actin in inner ear sensory organs and receptor cells was established by gel electrophoresis, by labelling with antibodies against actin, and by electron microscopy after decoration with subfragment-1 of Myosin to determine the functional orientation ofActin filaments found to be present in the mechanosensitive region of the receptor cells. Expand
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