Motile kinetochores and polar ejection forces dictate chromosome position on the vertebrate mitotic spindle

@article{Rieder1994MotileKA,
  title={Motile kinetochores and polar ejection forces dictate chromosome position on the vertebrate mitotic spindle},
  author={C L Rieder and Edward D. Salmon},
  journal={The Journal of Cell Biology},
  year={1994},
  volume={124},
  pages={223 - 233}
}
We argue that hypotheses for how chromosomes achieve a metaphase alignment, that are based solely on a tug-of-war between poleward pulling forces produced along the length of opposing kinetochore fibers, are no longer tenable for vertebrates. Instead, kinetochores move themselves and their attached chromosomes, poleward and away from the pole, on the ends of relatively stationary but shortening/elongating kinetochore fiber microtubules. Kinetochores are also "smart" in that they switch between… CONTINUE READING
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Chromosome alignment at mitotic metaphase: balanced forces or smart kinetochores? In Cell Movement. Volume 2: Kinesin, Dynein, and Microtubule Dynamics

  • T. J. Mitchison
  • 1989
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