Motifs that mediate dendritic targeting in hippocampal neurons: a comparison with basolateral targeting signals.

@article{Silverman2005MotifsTM,
  title={Motifs that mediate dendritic targeting in hippocampal neurons: a comparison with basolateral targeting signals.},
  author={Michael A. Silverman and Ron Peck and Greta Glover and C He and Cathleen Carlin and Gary Banker},
  journal={Molecular and cellular neurosciences},
  year={2005},
  volume={29 2},
  pages={173-80}
}
One model for dendritic protein sorting in neurons is based on parallels with basolateral targeting in Madin-Darby Canine Kidney (MDCK) epithelial cells. The goal of this study was to further evaluate this model by analyzing the neuronal targeting of several proteins that contain well-defined basolateral sorting motifs. When we expressed FcRgammaII-B2 and CD44, two basolateral markers whose sorting depends on dihydrophobic motifs, they were unpolarized in hippocampal neurons. We also assessed… CONTINUE READING
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