Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions.

@article{Schneider2004MotifsOT,
  title={Motifs of two small residues can assist but are not sufficient to mediate transmembrane helix interactions.},
  author={Dirk Schneider and Donald M. Engelman},
  journal={Journal of molecular biology},
  year={2004},
  volume={343 4},
  pages={799-804}
}
Both experimental and statistical searches for specific motifs that mediate transmembrane helix-helix interactions showed that two glycine residues separated by three intervening residues (GxxxG) provide a framework for specific interactions. Further work suggested that other motifs of small residues can mediate the interaction of transmembrane domains, so that the AxxxA-motif could also drive strong interactions of alpha-helices in soluble proteins. Thus, all these data indicate that a motif… CONTINUE READING

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