Motif module map reveals enforcement of aging by continual NF-kappaB activity.

@article{Adler2007MotifMM,
  title={Motif module map reveals enforcement of aging by continual NF-kappaB activity.},
  author={Adam S. Adler and Saurabh Sinha and Tiara L. A. Kawahara and Jennifer Gale Yan - Ling Zhang and Eran Segal and Howard Y Chang},
  journal={Genes & development},
  year={2007},
  volume={21 24},
  pages={3244-57}
}
Aging is characterized by specific alterations in gene expression, but their underlying mechanisms and functional consequences are not well understood. Here we develop a systematic approach to identify combinatorial cis-regulatory motifs that drive age-dependent gene expression across different tissues and organisms. Integrated analysis of 365 microarrays spanning nine tissue types predicted fourteen motifs as major regulators of age-dependent gene expression in human and mouse. The motif most… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 99 extracted citations

Similar Papers

Loading similar papers…