Motif-directed redesign of enzyme specificity

  title={Motif-directed redesign of enzyme specificity},
  author={Benjamin Borgo and James J Havranek},
  booktitle={Protein science : a publication of the Protein Society},
Computational protein design relies on several approximations, including the use of fixed backbones and rotamers, to reduce protein design to a computationally tractable problem. However, allowing backbone and off-rotamer flexibility leads to more accurate designs and greater conformational diversity. Exhaustive sampling of this additional conformational… CONTINUE READING