Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome

@article{Rach2008MotifCC,
  title={Motif composition, conservation and condition-specificity of single and alternative transcription start sites in the Drosophila genome},
  author={Elizabeth A. Rach and Hsiang-Yu Yuan and William H. Majoros and Pavel Tomançak and Uwe Ohler},
  journal={Genome Biology},
  year={2008},
  volume={10},
  pages={R73 - R73}
}
Transcription initiation is a key component in the regulation of gene expression. mRNA 5' full-length sequencing techniques have enhanced our understanding of mammalian transcription start sites (TSSs), revealing different initiation patterns on a genomic scale. To identify TSSs in Drosophila melanogaster, we applied a hierarchical clustering strategy on available 5' expressed sequence tags (ESTs) and identified a high quality set of 5,665 TSSs for approximately 4,000 genes. We distinguished… CONTINUE READING

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