Motif-based protein ranking by network propagation

  title={Motif-based protein ranking by network propagation},
  author={Rui Kuang and Jason Weston and William Stafford Noble and Christina S. Leslie},
  volume={21 19},
MOTIVATION Sequence similarity often suggests evolutionary relationships between protein sequences that can be important for inferring similarity of structure or function. The most widely-used pairwise sequence comparison algorithms for homology detection, such as BLAST and PSI-BLAST, often fail to detect less conserved remotely-related targets. RESULTS In this paper, we propose a new general graph-based propagation algorithm called MotifProp to detect more subtle similarity relationships… CONTINUE READING