Mothers, orphans, and prevention of paediatric AIDS

  title={Mothers, orphans, and prevention of paediatric AIDS},
  author={Karen Palmore Beckerman},
  journal={The Lancet},

The global reach of HIV: preventing mother-to-child transmission.

  • J. Kriebs
  • Medicine
    The Journal of perinatal & neonatal nursing
  • 2002
The natural history of mother-to-child transmission in HIV, including the role of breastfeeding and the effectiveness of various treatment/prevention schemes in resource-poor communities is discussed.

Editorial: Giving antiretrovirals in the peripartum period to prevent mother‐to‐child HIV transmission in low‐income countries: only a short‐term stopgap measure

Offering highly active antiretroviral treatment (HAART) to pregnant women and their partners will improve the quality of life of HIV-infected parents and improve their parenting efforts, decrease child mortality and the number of orphans because parents remain alive and healthy.

HIV-Associated Tuberculosis in the Newborn and Young Infant

Maternal mortality rates due to tuberculosis (TB) and HIV in Sub-Saharan Africa now supersede obstetric-related causes of mortality and both HIV and TB must be prevented.

The use of short-course zidovudine to prevent perinatal transmission of human immunodeficiency virus in rural Kenya.

The findings suggest that implementation of programs for prevention of mother-to-child transmission of HIV in rural areas of Africa need to consider the various socioeconomic and cultural barriers that may prevent successful uptake of antiretroviral prophylaxes.

Perinatal HIV: special considerations.

  • D. Cohan
  • Medicine
    Topics in HIV medicine : a publication of the International AIDS Society, USA
  • 2003
The growing body of data on pregnancy and HIV may indicate a rising commitment to research of and support for the unique challenges HIV-infected families face.

Tuberculosis and tuberculosis/HIV co-infection in pregnancy.

  • M. Adhikari
  • Medicine
    Seminars in fetal & neonatal medicine
  • 2009

The Changing Trends of HIV Subtypes and Its Implication on Mother-to-Child Transmission

The first cases of Acquired Immune Deficiency Syndrome (AIDS) were described in the United States in 19811. In Kenya, the first case was recognized in 19842 and since that time, Human

Emerging resistance to nonnucleoside reverse transcriptase inhibitors: a warning and a challenge.

Reduced susceptibility to efavirenz was associated with decreased virologic suppression, and efAvirenz hypersusceptibility wasassociated with virologics response to treatment, and the effectiveness of the NNRTI class is impressive but not surprising.

Children orphaned by AIDS: a global perspective.

Strengthening existing family and community capacity to assist orphans in Africa should be the first priority and saving the lives of parents through access to antiretroviral therapies in resource-poor countries in conjunction with bold support for alleviation of poverty and education must be an integral part of the global response to the orphan crisis.



Consensus statement on antiretroviral treatment for AIDS in poor countries.

With soaring death rates from HIV/AIDS in low-income countries both the prevention of transmission of the virus and the treatment of those already infected must be global public health priorities.

Selection and fading of resistance mutations in women and infants receiving nevirapine to prevent HIV-1 vertical transmission (HIVNET 012)

NVPR was detected more frequently in infants than women following NVP prophylaxis, and different patterns of NVPR mutations were detected in women versus infants, and NVP-resistant HIV-1 faded from detection in women and infants over time.

Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population

A substantial proportion of homeless and marginally housed individuals had good adherence to PI therapy and a strong relationship was found between independent methods of measuring adherence and concurrent viral suppression.

Perinatal transmission of human immunodeficiency virus type 1 by pregnant women with RNA virus loads <1000 copies/ml.

Perinatal HIV-1 transmission occurs in only 1% of treated women with RNA virus loads <1000 copies/mL and may be almost eliminated with antiretroviral prophylaxis accompanied by suppression of maternal viremia.

Nonnucleoside Reverse Transcriptase Inhibitor Resistance

It is suggested that continued use of NNRTIs after emergence of resistance will produce variants of complex mutational patterns that limit future treatment options, and, therefore, strong consideration should be given to discontinuing NN RTIs after virologic failure is confirmed.