Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines.

@article{Lecane2005MotexafinGA,
  title={Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines.},
  author={Philip S. Lecane and Mazen W. Karaman and Mint Sirisawad and Louie Naumovski and Richard A. Miller and Joseph G. Hacia and Darren J Magda},
  journal={Cancer research},
  year={2005},
  volume={65 24},
  pages={
          11676-88
        }
}
There is an emerging appreciation of the importance of zinc in regulating cancer cell growth and proliferation. Recently, we showed that the anticancer agent motexafin gadolinium (MGd) disrupted zinc metabolism in A549 lung cancer cells, leading, in the presence of exogenous zinc, to cell death. Here, we report the effect of MGd and exogenous zinc on intracellular levels of free zinc, oxidative stress, proliferation, and cell death in exponential phase human B-cell lymphoma and other… Expand
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