Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype.

@article{Kummer1997MostPC,
  title={Most primary cutaneous CD30-positive lymphoproliferative disorders have a CD4-positive cytotoxic T-cell phenotype.},
  author={Jean Alain Kummer and Maarten H. Vermeer and D Dukers and Chris J L M Meijer and Rein Willemze},
  journal={The Journal of investigative dermatology},
  year={1997},
  volume={109 5},
  pages={636-40}
}
Primary cutaneous CD30-positive (anaplastic) large T-cell lymphomas and lymphomatoid papulosis are closely related types of cutaneous T-cell lymphoma with a favorable prognosis. The neoplastic T cells in these conditions have the phenotype of activated CD3+, CD4+, CD8-, CD30+ skin homing T cells, but their normal counterpart has not yet been defined. To further characterize the cellular origin of the neoplastic T cells, skin biopsies from 14 patients with primary cutaneous CD30-positive… CONTINUE READING

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