Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits.

@article{Robinson2016MostNH,
  title={Most neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits.},
  author={James E Robinson and Kathryn M Hastie and Robert W. Cross and Rachael E. Yenni and Deborah H Elliott and Julie A. Rouelle and Chandrika B Kannadka and Ashley A Smira and Courtney E Garry and Benjamin T Bradley and Haini Yu and Jeffrey G Shaffer and Matt L. Boisen and Jessica N. Hartnett and Michelle A Zandonatti and Megan M Rowland and Megan L Heinrich and Luis Mart{\'i}nez-Sobrido and Benson Yee Hin Cheng and Juan Carlos de la Torre and Kristian G Andersen and Augustine Goba and Mambu Momoh and Mohamed Fullah and Michael Gbakie and Lansana D Kanneh and Veronica J. Koroma and Richard Fonnie and Simbirie C Jalloh and Brima Kargbo and Mohamed A. Vandi and Momoh Gbetuwa and Odia Ikponmwosa and Danny Asogun and Peter O Okokhere and Onikepe A Follarin and John S. Schieffelin and Kelly R. Pitts and Joan B. Geisbert and Peter C Kulakoski and Russell B. Wilson and Christian Tientcha Happi and Pardis C Sabeti and Sahr M. Gevao and Sheik Humarr Khan and Donald S Grant and Thomas W. Geisbert and Erica Ollmann Saphire and Luis M Branco and Robert F Garry},
  journal={Nature communications},
  year={2016},
  volume={7},
  pages={
          11544
        }
}
Lassa fever is a severe multisystem disease that often has haemorrhagic manifestations. The epitopes of the Lassa virus (LASV) surface glycoproteins recognized by naturally infected human hosts have not been identified or characterized. Here we have cloned 113 human monoclonal antibodies (mAbs) specific for LASV glycoproteins from memory B cells of Lassa fever survivors from West Africa. One-half bind the GP2 fusion subunit, one-fourth recognize the GP1 receptor-binding subunit and the… CONTINUE READING

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