Most hydrogen peroxide-induced histone H2AX phosphorylation is mediated by ATR and is not dependent on DNA double-strand breaks.

@article{Katsube2014MostHP,
  title={Most hydrogen peroxide-induced histone H2AX phosphorylation is mediated by ATR and is not dependent on DNA double-strand breaks.},
  author={Takanori Katsube and Masahiko Mori and Hideo Tsuji and Tadahiro Shiomi and Bing Wang and Qiang Liu and Mitsuru Nenoi and Makoto Onoda},
  journal={Journal of biochemistry},
  year={2014},
  volume={156 2},
  pages={85-95}
}
The nuclear foci of phosphorylated histone H2AX (γH2AX) are frequently used as a marker for DNA double-strand breaks (DSBs) following ionizing radiation (IR). However, recent studies reported that γH2AX foci do not necessarily correlate with DSBs under other conditions. We showed that γH2AX foci induced by oxidative stress in hydrogen peroxide (H2O2)-treated cells displayed several different features from those induced by IR. The magnitude of γH2AX induction was heterogeneous among H2O2-treated… CONTINUE READING

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