Most chronic urticaria is food‐dependent, and not idiopathic

@article{Henz1998MostCU,
  title={Most chronic urticaria is food‐dependent, and not idiopathic},
  author={Beate M. Henz and Torsten Zuberbier},
  journal={Experimental Dermatology},
  year={1998},
  volume={7}
}
Abstract: Although chronic urticaria is generally thought to be mostly idiopathic, we have recently provided convincing evidence that in the majority of patients, food ingredients provoke the symptoms and sustain the disease. On a diet largely avoiding preservatives, dyes and natural pseudoallergens, 73% of patients experienced remission of more than 6 months duration, starting within the first 3 weeks after initiation of the diet. This response rate is clearly higher than the reported 24… 
Effect of Diet in Chronic Spontaneous Urticaria: A Systematic Review.
TLDR
The level of evidence is low for the benefit of systematic diets in CSU because systematic double-blind controlled trials of diet are lacking and the only randomized studies were based on oral provocation tests with the suspected responsible diet.
A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria
TLDR
It is suggested that ingested histamine might be related to CU severity and that a histamine-free diet is helpful for treatment of adult patients with CU.
Effects of a pseudoallergen‐free diet on chronic spontaneous urticaria: a prospective trial
TLDR
Eliminating pseudoallergens from the diet can reduce symptom severity and improve patient quality of life.
Histamine plasma levels and elimination diet in chronic idiopathic urticaria
TLDR
The data suggest that histamine plays a major role in chronic idiopathic urticaria, and the finding of normal intestinal permeability suggests that a morphological damage of intestinal mucosa should be excluded in these patients.
Exacerbating Factors in Chronic Spontaneous Urticaria
TLDR
Effective treatment of CSU should involve the use of anti-histamines, intermittent steroids and anti-IgE therapy, and the 'talking therapies' that reduce stress and anxiety, vitamin D3 and iron supplementation, correction of intestinal dysbiosis and treatment of any chronic infection should also be considered.
Stress, pseudoallergens, autoimmunity, infection and inflammation in chronic spontaneous urticaria
TLDR
Effective treatment of CSU should involve the use of anti-histamines, intermittent steroids and anti-IgE therapy, and vitamin D3 supplementation, correction of intestinal dysbiosis and treatment of any chronic infection should also be considered.
Valor diagnóstico das provas de provocação com cápsulas de aditivos alimentares ou de níquel
TLDR
Oral challenge tests established the diagnosis of systemic contact dermatitis to nickel in 3 patients and food intolerance in 10 patients, and less restrictive diets could be followed in the long term.
Increased Allergic Sensitization to Mugwort in Chronic Urticaria
TLDR
Mugwort sensitization was associated with CU, possibly contributing to beneficial effect of elimination diets, and Ragweed, cat, rat and mite sensitization were also significantly associated withCU.
Diet in dermatology: Part II. Melanoma, chronic urticaria, and psoriasis.
TLDR
Weight loss, reduced alcohol consumption, and gluten avoidance as means of reducing psoriasis-associated morbidity, as well as the possible utility of supplementation with polyunsaturated fatty acids, folic acid, vitamin D, and antioxidants are explored.
Clinical and Laboratory Examinations in the Subgroups of Chronic Urticaria
TLDR
The autoimmune subgroup represents the most severe form of chronic urticaria, and there were no significant differences between the CIU and PU groups neither in urticsaria scores nor in response to antihistamine therapy.
...
1
2
3
...

References

SHOWING 1-10 OF 36 REFERENCES
Not all chronic urticaria is “idiopathic”
TLDR
A subset of chronic “idiopathic” urticaria patients are identified, representing approximately 30% of the total, in which the disease is caused by the presence of IgG autoantibodies against the high affinity IgE receptor (FcœRIα).
The pathogenesis of chronic idiopathic urticaria: new evidence suggests an auto–immune basis and implications for treatment
TLDR
Although some reduction in itching is experienced by most palients with severe urticaria even the newer 'low sedation' antihistamines have, at best, a modest influence on the appearance of the weals themselves, it is believed that reaction to food additives is other than a rare eause.
Oral cyclosporine for severe chronic idiopathic urticaria and angioedema.
TLDR
Although cyclosporine therapy is not an appropriate treatment of urticaria, the results of this preliminary study suggest that cyclospora and related drugs should be investigated in the treatment of mast cell-mediated diseases.
Neutrophilic urticaria: clinical features, histological changes and possible mechanisms
TLDR
Clinically, NU patients had a shorter mean duration of disease than other urticaria patients and significantly increased erythrocyte sedimentation rate and leucocytosis and immunohistochemistry characterized NU as an acute phase urticarial reaction associated with an intense inflammatory infiltrate and marked upregulation of some mast cell‐derived cytokines.
Treatment of severe, chronic urticaria with cyclosporin A
TLDR
The results of this preliminary study suggest that low dose cyclosporin results in improvement of severe, chronic urticaria in some patients.
Plasmapheresis for severe, unremitting, chronic urticaria
TLDR
Results favour a pathogenetic role for histamine-releasing autoantibodies in patients with chronic urticaria, as blood cellular histamine increased as in-vitro serum histamine -releasing activity fell after plasmapheresis.
Assessment of autoimmunity in patients with chronic urticaria.
TLDR
A large fraction of patients with chronic urticaria have antibody directed to Fc epsilon RI alpha that is functional and a smaller number have IgG anti-IgE (10%) and a third group may also have circulating factors capable of activating basophils or mast cells of which the identity is unknown.
Urticaria and asthma induced by food-and-drug additives in patients with aspirin hypersensitivity.
Abstract Seven of 8 recently investigated aspirin-sensitive patients reacted with asthma, urticaria, or both after 1 to 2 mg. of the azobenzene dye, tartrazine. Tartrazine is commonly used as a food
The pathology of the autologous serum skin test response in chronic urticaria resembles IgE-mediated late-phase reactions.
TLDR
The resemblance of the inflammation to the late phase of IgE-mediated immediate hypersensitivity reactions in atopics supports the concept that a circulating factor causes mast cell degranulation in chronic urticaria and may be important in the pathogenesis of the disorder.
Microscopic morphology of different types of urticaria.
TLDR
In all types of urticaria, mechanisms must be operative that cause an increase of cutaneous mast cells, and Distinctive pathological features can be identified in different types, although these are not diagnostic.
...
1
2
3
4
...