Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells.

@article{Sheng2015MostTM,
  title={Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells.},
  author={Jianpeng Sheng and Christiane Ruedl and Klaus Erik Karjalainen},
  journal={Immunity},
  year={2015},
  volume={43 2},
  pages={
          382-93
        }
}
Macrophages are one of the most diverse cell populations in terms of their anatomical location and functional specialization during both homeostasis and disease. Although it has been shown in different fate mapping models that some macrophages present in adult tissues are already established during fetal development, their exact origins are still under debate. In the current study, we developed a fate mapping strain, based on the Kit locus, which allowed us to readdress "the origins" question… CONTINUE READING
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Characterization of purified intraembryonic hematopoietic stem cells as a tool to define their site of origin.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL