Mosquito feeding modulates Th1 and Th2 cytokines in flavivirus susceptible mice: an effect mimicked by injection of sialokinins, but not demonstrated in flavivirus resistant mice

@article{Zeidner1999MosquitoFM,
  title={Mosquito feeding modulates Th1 and Th2 cytokines in flavivirus susceptible mice: an effect mimicked by injection of sialokinins, but not demonstrated in flavivirus resistant mice},
  author={N. Zeidner and S. Higgs and C. Happ and B. Beaty and B. Miller},
  journal={Parasite Immunology},
  year={1999},
  volume={21}
}
Culex pipiens and Aedes aegypti mosquitoes were fed on C3H/HeJ mice and systemic cytokine production was quantified from stimulated lymphocytes harvested four to ten days after feeding. Mosquito feeding on C3H/HeJ mice significantly down regulated IFNγ production seven to ten days post feeding by Cx. pipiens and seven days after Ae aegypti feeding. Th2 cytokines, IL‐4 and IL‐10, were significantly up regulated 4–7 days after Cx. pipiens and Ae. aegypti feeding. The immunosuppressive effect of… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Mosquito feeding-induced enhancement of Cache Valley Virus (Bunyaviridae) infection in mice.
TLDR
Enhanced CV infection in pregnant mice did not result in infertility or malformed pups, indicating that the mouse is not a suitable model to study CV-induced malformations and that replication of arboviruses in arthropod vectors may not be responsible for increased virulence of infections mediated by infected arthropods. Expand
Differential modulation of murine cellular immune responses by salivary gland extract of Aedes aegypti.
TLDR
Results confirm that mosquito SGE can modulate host immune responses, and suggest that in Ae. Expand
Suppression of Acute Ixodes scapularis-Induced Borrelia burgdorferi Infection using Tumor Necrosis Factor-α, Interleukin-2, and Interferon-γ
TLDR
The data suggest that cytokine-induced protection from B. burgdorferi infection was immune-mediated and that cellular immunity may be associated with protection from I. scapularis-induced infection. Expand
Suppression of acute Ixodes scapularis-induced Borrelia burgdorferi infection using tumor necrosis factor-alpha, interleukin-2, and interferon-gamma.
TLDR
The data suggest that cytokine-induced protection from B. burgdorferi infection was immune-mediated and that cellular immunity may be associated with protection from I. scapularis-induced infection. Expand
Genetic resistance to lethal flavivrus encephalitis. II. Effect of immunosuppression.
TLDR
The results indicate that genetic resistance of C3H/RV mice to Banzi virus requires immunological factors, and that T-cells play a significant role in resistance to infection withBanzi virus. Expand
Enhancement of tick‐borne encephalitis virus transmission by tick salivary gland extracts
TLDR
The results indicate that TBE virus transmission is enhanced by factor(s) associated with the salivary glands of feeding ticks, and that these factors may facilitate efficient transmission of TBEirus between infected and uninfected ticks even when they feed on hosts that have no detectable viraemia. Expand
Characterization of tick salivary gland factor(s) that enhance Thogoto virus transmission
TLDR
To investigate the physicochemical properties of the SAT factor, guinea pigs were infested with 50 uninfected R. appendiculatus nymphs and then inoculated with THO virus plus treated or untreated salivary gland extract, or with ThO virus alone. Expand
La Crosse viremias in white-tailed deer and chipmunks exposed by injection or mosquito bite.
TLDR
In this study, deer developed higher and longer viremia following exposure to LACV by infected Ae. Expand
Protection of adult but not newborn mice against lethal intracerebral challenge with Japanese encephalitis virus by adoptively transferred virus-specific cytotoxic T lymphocytes: requirement for L3T4+ T cells.
TLDR
The protective ability of cytotoxic T cells raised in vitro against Japanese encephalitis virus (JEV) was examined by adoptive transfer experiments and it was demonstrated that both Lyt 2.2+ and L3T4+ T cells are necessary to confer protection. Expand
Neuropeptide modulation of Th1 and Th2 cytokines in peripheral blood mononuclear leucocytes in atopic dermatitis and non‐atopic controls
TLDR
It is concluded that these neuropeptides have a modest effect on T‐cell cytokine release and that their action is not cytokine‐specific. Expand
...
1
2
3
4
5
...