Mosquito coil smoke inhalation toxicity. Part II: Subchronic nose‐only inhalation study in rats

@article{Pauluhn2006MosquitoCS,
  title={Mosquito coil smoke inhalation toxicity. Part II: Subchronic nose‐only inhalation study in rats},
  author={J{\"u}rgen Pauluhn and Ulrich Mohr},
  journal={Journal of Applied Toxicology},
  year={2006},
  volume={26}
}
  • J. Pauluhn, U. Mohr
  • Published 1 May 2006
  • Chemistry, Medicine
  • Journal of Applied Toxicology
This paper addresses the results of a subchronic inhalation study in rats exposed to the smoke of burning mosquito coils manufactured in Indonesia. The objective of the study was a comparative assessment of different mosquito coils, including a blank coil, utilizing the OECD No. 413 testing paradigm, however, with the focus on hazard identification at a single maximum tolerated exposure concentration rather than concentration‐response. Groups of rats were nose‐only exposed 6 h a day, 5 days a… 
Mosquito coil smoke inhalation toxicity. Part I: Validation of test approach and acute inhalation toxicity
  • J. Pauluhn
  • Chemistry, Medicine
    Journal of applied toxicology : JAT
  • 2006
TLDR
The results obtained support the conclusion that the dynamic nose‐only mode of exposure is experimentally superior to the quasistatic whole‐body exposure mode which provides the least control over exposure atmospheres and the outcome highly contingent on selected experimental factors.
Histopathological and Haematological Effects of Mosquito Coil Smoke on Lungs - An Experimental Study on Albino Rats
TLDR
Dgenerative changes were obtained in lung tissue of all experimental rats with maximum effect in group Adequate measures should be taken to ensure minimal exposure to coil smoke during domestic use.
Assessment of Early Acute Lung Injury in Rats Exposed to Aerosols of Consumer Products: Attempt to Disentangle the “Magic Nano” Conundrum
In Germany in 2006 a series of rapidly developing and sometimes severe cases of pulmonary health impairment were observed after normal use of the “Magic Nano Glass & Ceramic” spray and “Magic Nano
Small difference in carcinogenic potency between GBP nanomaterials and GBP micromaterials
  • T. Gebel
  • Chemistry, Medicine
    Archives of Toxicology
  • 2012
TLDR
The chronic rat inhalation studies with GBP materials indicate that the difference in carcinogenic potency between GBP nanomaterials and GBP micromaterials is low, and this difference can be described by a factor of 2–2.5 referring to the dose metrics mass concentration.
Susceptibility of young and adult rat kidneys to impacts of mosquito coil fumes
TLDR
Investigation of the effect of exposure to mosquito coil fumes on the biochemical and histological structure of kidney in young and adult male rats showed a non-significant change in body weight gain and somatic indices, except for the heart somatic index that increased significantly in both ages compared to control groups.
Protective Effect of Gongronema Latifolium Leaf Extract on Rambo And Raid Mosquito Coil Smoke-Induced Liver Toxicity in Albino Rats .
A total of 30 albino rats were used for the experiment and were grouped into A, B and C. Group A rats represented the control group while groups B and C were exposed to different brands of mosquito
Essential oil based controlled-release non-toxic evaporating tablet provides effective repellency against Musca domestica.
TLDR
This study provides an assurance that the formulated EO-CRT could be effective not only in repelling the nuisance pest, M. domestica, in human dwellings, but also in minimizing the mechanical transmission of pathogens by it.
Design, development and assessment of an essential oil based slow release vaporizer against mosquitoes.
TLDR
An essential oil based novel liquid vaporizer formulation with citronella and eucalyptus oils has been developed using a computer aided Artificial Neural Network and Particle Swarm Optimization (ANN-PSO) algorithm approach aiming to predict the best optimized formulation (OF).
Indoor air pollution and the lung in low- and medium-income countries
TLDR
There is strong evidence that while coal burning is a risk factor for lung cancer, exposure to other biomass fuel smoke is less so, and there is some evidence that reduction of smoke exposure using improved cooking stoves reduces the risk of COPD and, possibly, acute lower respiratory infection in children.
Association between Mosquito Coils Use with Nasopharyngeal Carcinoma
TLDR
It was shown that mosquito coil use might increase the risk of nasopharyngeal carcinoma incidence by 2.58-fold, which is considered significant if P-value is <0.05.
...
1
2
...

References

SHOWING 1-10 OF 40 REFERENCES
Toxic effects of mosquito coil (a mosquito repellent) smoke on rats. II. Morphological changes of the respiratory system.
TLDR
Smoke-induced histopathological lesions, including an inflammation of the tracheal epithelium, atelectasis of the lung parenchyma, emphysema, increase ofAlveolar macrophages in the alveolar space and perivascular infiltration of polymorphonuclear cells were observed in the experimental rats.
Chronic Nose-only Inhalation Study in Rats, comparing Room-aged Sidestream Cigarette Smoke and Diesel Engine Exhaust
TLDR
In rats exposed to DEE, but not to RASS, the following series of events occurs: particle deposition in lungs → lung “overload” → pulmonary inflammation → tumorigenesis, without a significant modifying role of cell proliferation or DNA adduct formation.
Household insecticides: evaluation and assessment of inhalation toxicity: a workshop summary.
  • U. Achmadi, J. Pauluhn
  • Chemistry, Medicine
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 1998
TLDR
It has been concluded that the nose-only exposure technique provides the most cost-effective and controlled means to expose small laboratory animals to well defined atmospheres as long as the limitations of this technique are taken into account.
Mosquito coil emissions and health implications.
TLDR
Exposure to the smoke of mosquito coils similar to the tested ones can pose significant acute and chronic health risks, and pollutant concentrations resulting from burning mosquito coils could substantially exceed health-based air quality standards or guidelines.
Health effects of subchronic exposure to low levels of wood smoke in rats.
TLDR
Exposure to wood smoke caused minor but significant changes in Brown Norway rats, and further studies are needed to establish whether exposure to wood Smoke exacerbates asthmalike symptoms that resemble those described for children living in homes using wood stoves for heating and cooking.
Overview of inhalation exposure techniques: strengths and weaknesses.
  • J. Pauluhn
  • Chemistry, Medicine
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie
  • 2005
TLDR
This paper addresses major developments in the discipline of inhalation toxicology with particular emphasis on the state-of-the-art testing of complex mixtures.
Morphological changes in the respiratory system of mice after inhalation of mosquito-coil smoke.
TLDR
The intercellular fibrosis in the lung was increased in both the treated and sham groups at 6 months and became more severe at the later stages and an increase in vascularity of the alveolar wall was observed and fine granular debris was frequently present in theAlveolar space.
Overview of testing methods used in inhalation toxicity: from facts to artifacts.
  • J. Pauluhn
  • Biology, Medicine
    Toxicology letters
  • 2003
For smaller rodent species, homogenous in size and growth, small head or nose-only chambers are commonly used up to subchronic exposure durations, whereas larger whole-body exposure chambers are used
Acute inhalation studies with irritant aerosols: technical issues and relevance for risk characterization
TLDR
For irritant aerosols both the concentration and the particle size are equally important for the outcome of the test, independent of whether the endpoint chosen is lethality or BAL protein, as shown for mMDI and NDI.
Validation of an improved nose‐only exposure system for rodents
  • J. Pauluhn
  • Chemistry, Medicine
    Journal of applied toxicology : JAT
  • 1994
TLDR
The nose‐only inhalation chamber developed is suitable for short‐term and long‐term inhalation toxicity studies using small laboratory rodents with minimal consumption of test compound and provides maximal computer support and automatization, as well as robust aerosol collection conditions.
...
1
2
3
4
...