Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway

@article{Pai2012MoscatilinIM,
  title={Moscatilin inhibits migration and metastasis of human breast cancer MDA-MB-231 cells through inhibition of Akt and Twist signaling pathway},
  author={Hui-Chen Pai and Li-Hsun Chang and Chieh-Yu Peng and Ya-Ling Chang and Chien‐Chih Chen and Chien-Chang Shen and Che M. Teng and Shiow-Lin Pan},
  journal={Journal of Molecular Medicine},
  year={2012},
  volume={91},
  pages={347-356}
}
Breast cancer metastasis is more resistant to chemotherapy and radiotherapy than is cancer of the visceral tissues; therefore, new treatment strategies are urgently needed. Moscatilin, derived from the orchid Dendrobrium loddigesii, has shown anticancer activity. We evaluated the mechanism by which moscatilin suppresses the migration and metastasis of human breast cancer MDA-MB-231 cells in vitro and in vivo. We demonstrated that moscatilin significantly inhibits MDA-MB-231 cell migration by… 
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References

SHOWING 1-10 OF 28 REFERENCES
Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxel.
TLDR
This study identifies Twist as a positive transcriptional regulator of AKT2 expression, and Twist-AKT2 signaling is involved in promoting invasive ability and survival of breast cancer cells.
Moscatilin Induces Apoptosis in Human Colorectal Cancer Cells: A Crucial Role of c-Jun NH2-Terminal Protein Kinase Activation Caused by Tubulin Depolymerization and DNA Damage
TLDR
The results suggest that moscatilin induces apoptosis of colorectal HCT-116 cells via tubulin depolymerization and DNA damage stress and that this leads to the activation of JNK and mitochondria-involved intrinsic apoptosis pathway.
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
Down-regulation of TWIST decreases migration and invasion of laryngeal carcinoma Hep-2 cells by regulating the E-cadherin, N-cadherin expression
TLDR
Down-regulation of TWIST expression decreases migration and invasion of laryngeal carcinoma Hep-2 cells by regulation of the E-cadherin, N-cADherin expression.
Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells
TLDR
The identification of a novel role for TWIST, a basic helix–loop–helix protein, which plays a central role in cell type determination and differentiation, during generation of acquired resistance to taxol is reported, providing a therapeutic strategy to overcome acquired resistance through inactivation of TWIST expression in human cancer.
Direct regulation of TWIST by HIF-1α promotes metastasis
TLDR
Evidence is provided of a key signalling pathway involving HIF-1α and TWIST that promotes metastasis in response to intratumoural hypoxia that promotes epithelial–mesenchymal transition and metastastic phenotypes.
Alterations in Vascular Gene Expression in Invasive Breast Carcinoma
TLDR
The expression of HEyl in tumor endothelial cells is demonstrated and the ability of HEYL to both induce proliferation and attenuate programmed cell death of primary endothelial Cells in vitro is established.
...
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