Moscatilin from the Orchid Dendrobrium loddigesii Is a Potential Anticancer Agent

@article{Ho2003MoscatilinFT,
  title={Moscatilin from the Orchid Dendrobrium loddigesii Is a Potential Anticancer Agent},
  author={Chi Kuan Ho and Chieh-Chih Chen},
  journal={Cancer Investigation},
  year={2003},
  volume={21},
  pages={729 - 736}
}
The Dendrobrium species have been commonly used in traditional Chinese medicine as a tonic to nourish the stomach, replenish body fluid, and reduce fever. However, their application as possible therapeutic agents for the treatment of cancers has not been examined. In this study, we want to examine the efficacy of using moscatilin, a natural antiplatelet agent extracted from the stems of Dendrobrium loddigesii, as an anticancer agent. Our results have shown that moscatilin exerts potent… 
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References

SHOWING 1-10 OF 31 REFERENCES
Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275.
TLDR
L86-8275 directly inhibits immunoprecipitated Cdc2 kinase activity from G2/M synchronized MDA-MB-468 breast carcinoma cells and is at least 250-fold more potent than either quercetin or genistein.
Establishment and characteristics of a gastric cancer cell line (HuGC‐OOHIRA) producing high levels of G‐CSF, GM‐CSF, and IL‐6: The presence of autocrine growth control by G‐CSF
TLDR
This cell line would be very useful for understanding both the cellular and molecular basis for the production of various cytokines such as G‐CSF as well as cytokine‐dependent tumor proliferation.
Antiplatelet aggregation principles of Dendrobium loddigesii.
The MeOH extract of the stem of Dendrobium loddigesii was found to inhibit the aggregation of rabbit platelets induced by arachidonic acid and collagen. Two active compounds, moscatilin [1] and
Effect of suramin on p34cdc2 kinase in vitro and in extracts from human H69 cells: evidence for a double mechanism of action.
TLDR
Suramin strongly inhibits the catalytic activity of purified p34cdc2 kinase, whereas it only weakly inhibits the p13-agarose precipitated kinase activity from nuclear and cytoplasmic extracts of the asynchronous H69 human small cell lung cancer cells.
Staurosporine is a potent inhibitor of p34cdc2 and p34cdc2-like kinases.
Immunological analysis of glycolipids on cell surfaces of cultured human tumor cell lines: expression of lactoneotetraosylceramide on tumor cell surfaces.
TLDR
Findings suggest that nLc4Cer may be a tumor-associated lipid that is detected in cell lines of colonic adenocarcinoma, gastric tumor, and lung tumor and in ascitic fluids of cancer patients.
Activation of programmed cell death by anticancer agents: cisplatin as a model system.
TLDR
Cisplatin-induced cell death is reminiscent of apoptosis, or programmed cell death, and many other anticancer drugs produce the same phenotypic effects, suggesting that these agents may all interact with the same signal transduction pathway leading to cell death.
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
TLDR
Through its unique selectivity for some cyclin-dependent kinases, roscovitine provides a useful antimitotic reagent for cell cycle studies and may prove interesting to control cells with deregulated cdc2, cdk2 or cdk5 kinase activities.
Induction of plasma protein secretion in a newly established human hepatoma cell line
TLDR
The establishment of a new human hepatoma cell line, HA22T/VGH, has many of the properties of human hepatocellular carcinoma and provides a good experimental framework to investigate differentiation of human hepatocytes.
Moscatilin, a bibenzyl derivative from the orchid Dendrobium moscatum
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