Mosaics of gene variations in the Interleukin-10 gene promoter affect interleukin-10 production depending on the stimulation used

@article{Mrmann2004MosaicsOG,
  title={Mosaics of gene variations in the Interleukin-10 gene promoter affect interleukin-10 production depending on the stimulation used},
  author={Maik M{\"o}rmann and Horst Rieth and T. D. Hua and C Assohou and Maria Roupelieva and Shiu Lok Hu and Peter Gottfried Kremsner and Adriana J F Luty and Dieter Kube},
  journal={Genes and Immunity},
  year={2004},
  volume={5},
  pages={246-255}
}
Interleukin-10 (IL-10), a cytokine involved in many aspects of the immune response shows interindividual variations in their expression. However, genetic variations of the 5′-flanking region of the IL-10 gene (PIL-10) are poorly characterised with respect to different stimuli. New extended haplo- and genotypes are identified present at differing frequencies in three geographically separated populations. Their influence on IL-10 expression have been assessed in vitro after stimulation of… CONTINUE READING
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