Mosaicism of the retinal pigment epithelium: seeing the small picture.

@article{Burke2005MosaicismOT,
  title={Mosaicism of the retinal pigment epithelium: seeing the small picture.},
  author={Janice M. Burke and Leonard M. Hjelmeland},
  journal={Molecular interventions},
  year={2005},
  volume={5 4},
  pages={241-9}
}
The retinal pigment epithelium (RPE) is a monolayer of cells that appear phenotypically regular, but which exhibit striking cell-cell variability in content of melanin and lipofuscin granules, and in expression of many proteins. This naturally occurring cell heterogeneity likely arises by normal mechanisms regulating gene expression during development and postnatal aging. The consequence is a tissue in which individual cells may differ in their ability to support adjacent photoreceptors, and… CONTINUE READING