Mosaicism in human skin. Understanding the patterns and mechanisms.

  title={Mosaicism in human skin. Understanding the patterns and mechanisms.},
  author={Rudolf Happle},
  journal={Archives of dermatology},
  volume={129 11},
BACKGROUND The skin is especially suitable for the study of mosaicism. In this review, the various genetic mechanisms leading to mosaicism and the resulting cutaneous patterns are considered. OBSERVATIONS Mosaicism may produce different cutaneous patterns such as the lines of Blaschko, the checkerboard pattern, the phylloid pattern, and a patchy pattern without midline separation. A unique lateralization pattern is observed in the CHILD syndrome. Two major genetic categories are functional… CONTINUE READING
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