Mosaicism and accuracy of prenatal cytogenetic diagnoses after chorionic villus sampling and placental biopsies.

@article{Miny1991MosaicismAA,
  title={Mosaicism and accuracy of prenatal cytogenetic diagnoses after chorionic villus sampling and placental biopsies.},
  author={Peter Miny and Peter M Hammer and B{\"a}rbel Gerlach and Sevgi Tercanli and Juergen Horst and Wolfgang Holzgreve and Bernd Eiben},
  journal={Prenatal diagnosis},
  year={1991},
  volume={11 8},
  pages={581-9}
}
Discrepant chromosome findings in placenta and fetus (false negative and false positive) after chorionic villus sampling (CVS) are mainly due to confined mosaicism. Non-mosaic normal or abnormal chromosome counts after direct preparation and culture nearly always correctly reflect the fetal chromosome constitution. False-negative results have almost exclusively been restricted to cytotrophoblast cells not representing a fetal chromosome abnormality. Diagnosis of placental mosaicism definitely… CONTINUE READING