Mosaic tetrasomy 21 in severe mental handicap

  title={Mosaic tetrasomy 21 in severe mental handicap},
  author={J. P. Fryns and Paul Petit and L. Vinken and J. Geutjens and Jan Marien and H. Van den Berghe},
  journal={European Journal of Pediatrics},
A 5-year-old boy with severe mental handicap, dysmorphic stigmata and a tetrasomy 21 in fibroblasts is reported. Blood lymphocytes of the patient have a normal karyotype. The origin of this tetrasomy 21 mosaicism is discussed. 

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