• DOI:10.1103/PHYSREVE.49.1685
• Corpus ID: 3498343

Mosaic organization of DNA nucleotides.

@article{Peng1994MosaicOO,
  title={Mosaic organization of DNA nucleotides.},
  author={Chung-Kang Peng and Sergey V. Buldyrev and Shlomo Havlin and Michael Simons and H. Eugene Stanley and Ary L. Goldberger},
  journal={Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics},
  year={1994},
  volume={49 2},
  pages={
          1685-9
        }
}

• Chung-Kang Peng, S. Buldyrev, +3 authors A. Goldberger
• Published 1 February 1994
• Biology
• Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics

Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions. We address the question of whether such correlations may be a trivial consequence of the known mosaic structure ("patchiness") of DNA. We analyze two classes of controls consisting of patchy nucleotide sequences generated by different algorithms--one without and one with long-range power-law correlations. Although both types of sequences are highly heterogenous, they are quantitatively distinguishable by an alternative fluctuation analysis method that differentiates local patchiness from long-range correlations. Application of this analysis to selected DNA sequences demonstrates that patchiness is not sufficient to account for long-range correlation properties.