Mosaic loss of chromosome Y is associated with common variation near TCL1A

@inproceedings{Zhou2016MosaicLO,
  title={Mosaic loss of chromosome Y is associated with common variation near TCL1A},
  author={Weiyin Zhou and Mitchell J. Machiela and Neal D Freedman and Nathaniel Rothman and N{\'u}ria Malats and Casey L Dagnall and Neil E. Caporaso and Lauren T. Teras and Mia M Gaudet and Susan M. Gapstur and Victoria L Stevens and Kevin B. Jacobs and Joshua N. Sampson and Demetrius Albanes and Stephanie J Weinstein and Jarmo R Virtamo and Sonja I. Berndt and Robert Nathaniel Hoover and Amanda Black and Debra T. Silverman and Jonine D Figueroa and Montserrat Garc{\'i}a-Closas and Francisco X Real and Julie Earl and Gaelle Marenne and Benjam{\'i}n Rodr{\'i}guez-Santiago and Margaret R. Karagas and Alison Venable Johnson and Molly Schwenn and Xifeng Wu and Jian Gu and Yuanqing Ye and Amy A. Hutchinson and Margaret A. Tucker and Luis A. P{\'e}rez-Jurado and Michael Dean and Meredith Yeager and Stephen J. Chanock},
  booktitle={Nature Genetics},
  year={2016}
}
Mosaic loss of chromosome Y (mLOY) leading to gonosomal XY/XO commonly occurs during aging, particularly in smokers. We investigated whether mLOY was associated with non-hematological cancer in three prospective cohorts (8,679 cancer cases and 5,110 cancer-free controls) and genetic susceptibility to mLOY. Overall, mLOY was observed in 7% of men, and its prevalence increased with age (per-year odds ratio (OR) = 1.13, 95% confidence interval (CI) = 1.12–1.15; P < 2 × 10−16), reaching 18.7% among… CONTINUE READING

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