Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.

@article{Chang2000MosaicBV,
  title={Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood.},
  author={Y S Chang and Emmanuelle di Tomaso and D M Mcdonald and Rachel M Jones and Rakesh K. Jain and Lance L. Munn},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 26},
  pages={14608-13}
}
The presence of "mosaic" vessels in which both endothelial cells and tumor cells form the luminal surface has profound implications for metastasis, drug delivery, and antivascular therapy. Yet little is known of the frequency, and thus importance, of mosaic vessels in tumors. Using CD31 and CD105 to identify endothelial cells and endogenous green fluorescent protein labeling of tumor cells, we show that approximately 15% of perfused vessels of a colon carcinoma xenografted at two different… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, results, connections, and topics extracted from this paper.
228 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 228 extracted citations

Similar Papers

Loading similar papers…