Mortality rates in pediatric septic shock with and without multiple organ system failure

@article{Kutko2003MortalityRI,
  title={Mortality rates in pediatric septic shock with and without multiple organ system failure},
  author={Martha C. Kutko and Michael P. Calarco and Maryellen B. Flaherty and R F Helmrich and Henry Michael Ushay and Steven Pon and Bruce M. Greenwald},
  journal={Pediatric Critical Care Medicine},
  year={2003},
  volume={4},
  pages={333-337}
}
Objectives To determine the current mortality rates for pediatric patients with septic shock and the frequency and outcome of associated multiple organ system failure. Design Retrospective chart review. Setting Multidisciplinary pediatric intensive care unit. Patients Children age 1 month to 21 yrs admitted to the pediatric intensive care unit from January 1, 1998, to December 31, 1999, with a diagnosis of septic shock. Interventions None. Measurements and Main Results A database of all… 
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177 Citations
Highly Influential Citations
9
Background Citations
56
Methods Citations
2
Results Citations
5

177 Citations

Mortality rates in pediatric septic shock
TLDR
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Critically ill children with septic shock treated in a children's hospital ED who received antibiotics in ≤1 hour were significantly more severely ill than those treated later, but they did not have increased risk of NP-MODS or death.
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The findings on children treated in the pediatric intensive care unit conform with current literature about pediatric sepsis, such as the quick administration of empirical broad-spectrum antibiotics, initial adequate fluid resuscitation, and a reliable and frequent routine of source control.
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Gram-negative bacteria and Staphylococcus aureus predominated in the etiology and clinical disease progression variables of sepsis associated with the prognosis of patients admitted to a pediatric intensive care unit and the presence of complications was a factor associated with death.
Incidence of and mortality due to sepsis, severe sepsis and septic shock in Italian Pediatric Intensive Care Units: a prospective national survey
TLDR
It is suggested that application of the new definitions for sepsis diagnosis and diffusion of guidelines for early recognition and aggressive treatment of severe Sepsis and septic shock in Italy represent a high priority to reduce mortality.
Risk of Mortality in Immunocompromised Children With Severe Sepsis and Septic Shock
TLDR
Multiple prior malignancies, hemophagocytic lymphohistiocytosis, congenital immunodeficiency, and hematopoietic cell transplant are independently associated with an increased odds of PICU mortality in children with severe sepsis or septic shock.
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TLDR
Sepsis remain as leading cause of mortality in PICU and PRISMIII had the excellent prediction of death.
Intravenous Fluid Bolus Rates Associated with Outcomes in Pediatric Sepsis: A Multi-Center Analysis
TLDR
Faster ED IVF bolus administration rates in this pediatric sepsis database were associated with higher adjusted odds of death, intubation and NIPPV, and controlled trials are needed to determine if these associations are replicable.
Characteristics and Outcomes of Pediatric Septic Patients With Cancer: A Retrospective Cohort Study.
Epidemiology and Outcome of Sepsis in a Tertiary Care PICU of Pakistan
TLDR
The presence of septic shock and MODS is associated with high mortality in the PICU of developing countries, and the independent predictors of mortality were modeled using multiple logistic regression.
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