Mortality of workers exposed to polychlorinated biphenyls--an update.

@article{Brown1987MortalityOW,
  title={Mortality of workers exposed to polychlorinated biphenyls--an update.},
  author={D. P. Brown},
  journal={Archives of environmental health},
  year={1987},
  volume={42 6},
  pages={
          333-9
        }
}
  • D. Brown
  • Published 1 November 1987
  • Medicine
  • Archives of environmental health
A retrospective cohort mortality study of workers exposed to polychlorinated biphenyls (PCBs) in two plants manufacturing electrical capacitors was reported in 1981. The study was conducted primarily to examine the risk of cancer mortality associated with exposure to PCBs. Based on animal data, liver cancer was the disease of most interest. Due to the small number of deaths and a relatively short observation period, the study was considered inconclusive. This study has been updated by adding 7… 
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References

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TLDR
A retrospective cohort mortality study of 2,567 workers in two plants where PCBs were used in the manufacture of electrical capacitors found all-cause mortality was lower than expected and excess mortality for rectal cancer and liver cancer was noted, although neither excess was statistically significant.
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TLDR
The point of interest is the consistency of these results with previous experimental and epidemiologic studies, which indicated the GI tract and lymphatic and hemopoietic tissue as the most probable target sites of the PCBs carcinogenic activity.
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TLDR
The results cannot rule out the possibility of a carcinogenic risk from PCB exposure because of the small size of the cohort and relatively brief follow-up period, but they do not indicate any excess mortality or cancer incidence in this factory so far.
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TLDR
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TLDR
The total mortality rate and the incidence of thymoma, inflammatory lesions of the urogenital tract, in the experiment were significantly reduced by Clophen administration, whether this protective effect could be induced by polychlorinated biphenyls (PCBs) is discussed.
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TLDR
Because of their low volatility, their chemical stability, and lipid solubility, PCBs have been detected in eco-systems, showing biological magnification as one examines residues in food chains.
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TLDR
Within the Sprague-Dawley rat group exposed to a diet with relatively high concentrations of Aroclor 1260 for 2 years a hepatocarcinogenic effect manifested by formation of slowly growing hepatocellular carcinomas was produced.
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TLDR
The results indicate that the sex-dependent promoting effect of Clophen A 50 is independent from its mitogenic action, and may indicate a weak carcinogenic potency.
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TLDR
The polychlorinated biphenyl Aroclor 1260, when fed in the diet, had a hepatocarcinogenic effect in Sherman strain female rats, and the incidence of tumors in other organs did not differ appreciably between the experimental and control groups.
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TLDR
PCBs themselves induced hepatic neoplasms in mice and also promoted the induction of tumors bya-BHC and p-B HC.
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