Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis

@article{Newell2004MortalityOI,
  title={Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis},
  author={Marie-Louise Newell and Hoosen Mohamed Coovadia and M. Cortina-Borja and Nigel C Rollins and Philippe Gaillard and François Dabis},
  journal={The Lancet},
  year={2004},
  volume={364},
  pages={1236-1243}
}
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Mortality in HIV-Infected and Uninfected Children of HIV-Infected and Uninfected Mothers in Rural Uganda
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More than half of HIV-infected infants born to HIV+ and HIV− mothers in Uganda died at less than 2 years of age and ART may need to be initiated earlier in HIV- Infected African children.
Children Who Acquire HIV Infection Perinatally Are at Higher Risk of Early Death than Those Acquiring Infection through Breastmilk: A Meta-Analysis
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It is highlighted the urgent need for the prevention of peri-partum and postnatal transmission and timely assessment of HIV infection in infants to initiate antiretroviral care and support for HIV-infected children.
Does severity of HIV disease in HIV-infected mothers affect mortality and morbidity among their uninfected infants?
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  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2005
TLDR
Children born to HIV-infected mothers with advanced disease who escaped perinatal or early breastfeeding-related HIV infection are nonetheless at high risk of mortality and morbidity during the first few months of life.
Treating HIV-Infected Mothers Reduces under 5 Years of Age Mortality Rates to Levels Seen in Children of HIV-Uninfected Mothers in Rural South Africa
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Findings highlight the importance of maternal HIV treatment with direct benefits of improved survival among all children under-5 and suggest timely HIV treatment for eligible women is required to benefit both mothers and children.
Morbidity and Mortality Among a Cohort of Human Immunodeficiency Virus Type 1-Infected and Uninfected Pregnant Women and Their Infants From Malawi, Zambia, and Tanzania
TLDR
The high mortality among infants with early HIV-1 infection supports access to HIV- 1 diagnostics and appropriate early treatment for all infants of HIV-2-infected mothers and the significant association between stage of maternal HIV-3 infection and infant mortality supports routine CD4 counts at the time of prenatal HIV-0 testing.
Treatment Failures and Excess Mortality Among HIV-Exposed, Uninfected Children With Pneumonia.
TLDR
HIV-EU children with pneumonia have higher rates of treatment failure and in-hospital mortality than HIV-unexposed children during the first 6 months of life and treatment with a third-generation cephalosporins did not improve outcomes among HIV- EU children.
Morbidity and mortality among infants born to HIV-infected women in South Africa: implications for child health in resource-limited settings.
TLDR
Future interventions that minimize pediatric HIV infection and reduce maternal viremia, which are the main predictors of child health soon after birth, will impact positively on infant health outcomes.
Survival of HIV Infected Children Born to Mothers Enrolled in a PMTCT Program in a Resource Poor Setting
TLDR
There was unacceptable high mortality from HIV infected children and loss to follow up prior to availability of HAART in this setting, and a small proportion of HIV vertically infected children is surviving in resource poor settings without antiretroviral therapy.
High Burden of Morbidity and Mortality but Not Growth Failure in Infants Exposed to but Uninfected with Human Immunodeficiency Virus in Tanzania
Survival from 9 months of age among HIV-infected and uninfected Zambian children prior to the availability of antiretroviral therapy.
  • C. Sutcliffe, S. Scott, W. Moss
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2008
TLDR
Only approximately one-half of HIV-infected Zambian children who were alive at 9 months of age survived to 3 years of age, supporting the urgent need for the prevention of mother-to-child transmission of HIV and the early diagnosis and treatment of HIV infection in children in sub-Saharan Africa.
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