Mortality in Patients with Hemophilia: Changes in a Dutch Population from 1986 to 1992 and 1973 to 1986

@article{Triemstra1995MortalityIP,
  title={Mortality in Patients with Hemophilia: Changes in a Dutch Population from 1986 to 1992 and 1973 to 1986},
  author={M. Triemstra and F. Rosendaal and C. Smit and H. van der Ploeg and E. Briet},
  journal={Annals of Internal Medicine},
  year={1995},
  volume={123},
  pages={823-827}
}
  • M. Triemstra, F. Rosendaal, +2 authors E. Briet
  • Published 1995
  • Medicine
  • Annals of Internal Medicine
  • Before 1960, hemophilia was characterized by excess mortality caused by hemorrhages, mainly intracranial [1, 2]. Substitution therapy, introduced in the 1960s, has contributed to a decrease in hemophilia-related mortality [3-8]. However, survival decreased sharply in the 1980s because of deaths from human immunodeficiency virus (HIV) infection or hepatitis, particularly in patients with severe hemophilia [5, 7]. The acquired immunodeficiency syndrome (AIDS) caused an increase in mortality rates… CONTINUE READING
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