Mortality from Second Tumors Among Long-Term Survivors of Retinoblastoma

  title={Mortality from Second Tumors Among Long-Term Survivors of Retinoblastoma},
  author={Charis Eng and Frederick P. Li and David H Abramson and Robert M Ellsworth and Florence Lennie Wong and Marlene B. Goldman and Johanna M. Seddon and Nancy J. Tarbell and John Dunning Boice},
  journal={Journal of the National Cancer Institute},
  volume={85 14},
BACKGROUND Children diagnosed with retinoblastoma, a rare cancer of the eye, tend to develop and die of second primary cancers in childhood and adolescence, but few investigations have followed patients into adulthood. Retinoblastoma is frequently caused by inherited mutations of the RB1 tumor suppressor gene. Most patients with germline (hereditary) mutations have bilateral disease. PURPOSE We sought to quantify the mortality from second malignancies among long-term survivors of… CONTINUE READING


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