Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.

  title={Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.},
  author={Debra S Echt and Philip R. Liebson and L. Brent Mitchell and Robert Mattson Peters and Dulce Obias-Manno and Allan H. Barker and Daniel Arensberg and Alfred Baker and Lawrence S. Friedman and Harry L. Greene},
  journal={The New England journal of medicine},
  volume={324 12},
BACKGROUND AND METHODS In the Cardiac Arrhythmia Suppression Trial, designed to test the hypothesis that suppression of ventricular ectopy after a myocardial infarction reduces the incidence of sudden death, patients in whom ventricular ectopy could be suppressed with encainide, flecainide, or moricizine were randomly assigned to receive either active drug or placebo. The use of encainide and flecainide was discontinued because of excess mortality. We examined the mortality and morbidity after… CONTINUE READING
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