Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data

@article{Head2018MortalityAC,
  title={Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data},
  author={Stuart J. Head and Milan Milojevic and Joost Daemen and Jung‐Min Ahn and Eric Boersma and Evald H{\o}i Christiansen and Michael J. Domanski and Michael E Farkouh and Marcus D Flather and Valent{\'i}n Fuster and Mark A. Hlatky and Niels Ramsing Holm and Whady Hueb and Masoor Kamalesh and Young-Hak Kim and Timo M{\"a}kikallio and Friedrich W. Mohr and Grigorios Papageorgiou and Seung‐Jung Park and Alfredo E. Rodr{\'i}guez and Joseph F Sabik and Rodney Hilton Stables and Gregg W. Stone and Patrick Wjc Serruys and Arie Pieter Kappetein},
  journal={The Lancet},
  year={2018},
  volume={391},
  pages={939-948}
}

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TLDR
This analysis compares 5-year clinical outcomes in PCI- and CABG-treated LM patients in the Synergy Between PCI With Taxus and Cardiac Surgery (SYNTAX) trial and suggests that both treatments are valid options for LM patients.
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CABG remains the standard of care for patients with three-vessel or left main coronary artery disease, since the use of CABG, as compared with PCI, resulted in lower rates of the combined end point of major adverse cardiac or cerebrovascular events at 1 year.
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TLDR
Five-year results of patients with 3VD treated with CABG or PCI using the first-generation paclitaxel-eluting DES suggest that CABGs should remain the standard of care as it resulted in significantly lower rates of death, MI, and repeat revascularization, while stroke rates were similar.
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TLDR
In this pooled analysis of 4 randomized trials, PCI with stenting was associated with a long-term safety profile similar to that of CABG, however, as a result of persistently lower repeat revascularization rates in the C ABG patients, overall major adverse cardiac and cerebrovascular event rates were significantly lower in theCABG group at 5 years.
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TLDR
In this randomized trial involving patients with unprotected left main coronary artery stenosis, PCI with sirolimus-eluting stents was shown to be noninferior to CABG with respect to major adverse cardiac or cerebrovascular events, but the results cannot be considered clinically directive.
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