Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity.

@article{Wang2009MorronisidePH,
  title={Morroniside protects human neuroblastoma SH-SY5Y cells against hydrogen peroxide-induced cytotoxicity.},
  author={Wen Wang and Fangling Sun and Yi An and Houxi Ai and Li Zhang and Wenting Huang and Lin Li},
  journal={European journal of pharmacology},
  year={2009},
  volume={613 1-3},
  pages={19-23}
}
Oxidative stress-induced cell damage has been implicated in a variety of neurodegenerative disorders. Morroniside, an iridorid glycoside isolated from Cornus officinalis Sieb. Et Zucc., has shown potent antioxidant properties. The present study investigated the protective actions of morroniside against the cytotoxicity produced by exposure to H(2)O(2) (300-500 microM) in SH-SY5Y cells. Intracellular accumulation of Ca(2+), and decreases in mitochondrial membrane potential (MMP) caused by added… CONTINUE READING
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Isolation and structure identification of the chemical constituents from Cornus officinalis

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