Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia

@article{Ikeda2001MorphometricalRO,
  title={Morphometrical reappraisal of motor neuron system of Pick's disease and amyotrophic lateral sclerosis with dementia},
  author={Kenji Ikeda and Haruhiko Akiyama and Tetsuaki Arai and Hideki Ueno and Kuniaki Tsuchiya and Kenji Kosaka},
  journal={Acta Neuropathologica},
  year={2001},
  volume={104},
  pages={21-28}
}
The conventional concept of Pick's disease does not distinguish Pick's disease with Pick bodies (Pick body disease, PBD) from Pick's disease without Pick bodies [lobar atrophy without Pick bodies, LA-PB(-)]. Recently, intraneuronal ubiquitin-positive inclusions (ub-inclusions), which are thought to be a hallmark of amyotrophic lateral sclerosis with dementia (ALS-D), have been found also in LA-PB(-). We reconfirmed that ub-inclusions are consistently detected in LA-PB(-) as well as ALS-D… CONTINUE READING