Morphometric study of human cerebral cortex development

  title={Morphometric study of human cerebral cortex development},
  author={Peter R. Huttenlocher},
  • P. Huttenlocher
  • Published 31 December 1990
  • Biology, Psychology
  • Neuropsychologia

Neuronal network formation in human cerebral cortex.

  • G. Ramakers
  • Biology, Psychology
    Progress in brain research
  • 2005

Functional brain development in humans

The infant's interaction with its environment helps to sculpt inter- and intraregional connections within the cortex, eventually resulting in the highly specialized adult brain.

Refinement of neuronal networks in the rodent prefrontal cortex and hippocampus

It is shown for the first time that the timing as well as the amount of social contact with family members significantly interferes with the refinement of prefrontal cortical and hippocampal synaptic development in weaning children.

Maturation of the human brain and epilepsy.

Is postnatal neocortical maturation hierarchical?

  • R. Guillery
  • Biology, Psychology
    Trends in Neurosciences
  • 2005

Neural substrates of early executive function development

Development Period of Prefrontal Cortex

  • M. Uytun
  • Psychology, Biology
    Prefrontal Cortex
  • 2018
This chapter outlines the issues associated with the development of prefrontal cortex in children and adolescents, and describes the developmental profile of executive pro cesses across childhood, the changes in structural architecture, neural activity, and cognitive abilities.

Imaging the developing brain: what have we learned about cognitive development?

Development of Microstructural and Morphological Cortical Profiles in the Neonatal Brain

Changes in cortical network architecture over an eight-week period are consistent with, and likely underpin, the highly dynamic behavioural and cognitive development occurring during this critical period of perinatal brain development.



Synapse elimination and plasticity in developing human cerebral cortex.

  • P. Huttenlocher
  • Biology, Psychology
    American journal of mental deficiency
  • 1984
Overproduction of synapses may impart plasticity to the brain of young children and this property of developing brain may be exploited for retraining when function is impaired.

Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex.

This isochronic course of synaptogenesis in anatomically and functionally diverse regions indicates that the entire cerebral cortex develops as a whole and that the establishment of cell-to-cell communication in this structure may be orchestrated by a single genetic or humoral signal.

The development of synapses in striate cortex of man.

The findings support the hypothesis that exuberant synaptic connections are an anatomical substrate for plasticity in developing cerebral cortex.

The density of synapses and neurons in normal, mentally defective ageing human brains.

  • B. Cragg
  • Biology, Psychology
    Brain : a journal of neurology
  • 1975
The densities of synapses and neurons were measured in 7 neurosurgical specimens of cerebral cortex, regarded as normal controls, and a deficit of synaptic development was not a necessarre discussed.

Dendritic Spine "Dysgenesis" and Mental Retardation

Golgi studies reveal abnormally long, thin spines and the absence of short, thick spines on dendrites of cortical neurons in retarded children with normal karyotypes in relation to age and the severity of developmental retardation.


The results clearly demonstrate that there is a massive neuronal loss in the cerebral cortex during early postnatal development, greater in layers II‐IV than in layers V‐VI.