Morphometric evaluation of brain infarcts in rats and gerbils.

  title={Morphometric evaluation of brain infarcts in rats and gerbils.},
  author={Edward F. Lundy and B S Solik and Rexann S Frank and P S Lacy and David J. Combs and Gerald B. Zelenock and L G D'alecy},
  journal={Journal of pharmacological methods},
  volume={16 3},
The Levine rat preparation, the gerbil stroke model, and appropriate control animals were used to determine if the 2,3,5-triphenyltetrazolium chloride (TTC) would selectively identify noninfarcted versus infarcted cerebral tissue. The TTC is frequently used to quantify infarcted myocardial tissue and has been shown to have great specificity, reproducibility, and efficacy. The TTC produces a red product upon reaction with the respiratory enzymes (dehydrogenases) present in non-infarcted tissues… CONTINUE READING